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23,24,25 In hyperglycemia, innate immune system activation, particularly through nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasomes, 26 promotes the release of pro-inflammatory factors, aggravating chronic inflammation, immune senescence, 27 vascular damage, and target organ injury

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Nitrofurantoin already causes GI side effects in approximately 10 to 15 percent of patients, and Macrodantin (the immediate-release form) more so than Macrobid